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Jeff is one of the rare executives whose career has spanned most key verticals in global healthcare with executive committee and other senior roles at UnitedHealth Group, Walgreens Boots Alliance and Merck. He also serves on the boards of the privately held ZappRx and Braeburn. Former Senior Associate, the Trout Group.
Prior to joining Trout, Mr. Cedarbaum obtained his medical degree from Yale Medical School, where he is currently Professor Adjunct of Psychiatry. Cedarbaum then joined Regeneron, where he led the establishment of the clinical development function and served as Program Director and later Vice President of Clinical Affairs.
Cedarbaum has authored or co-authored over peer-reviewed scientific publications, most in the area of neurotherapeutics. He also has more than 20 years of experience as an investment banker working extensively in corporate finance, capital markets and financial analysis. Fiel is a distinguished physician and author of numerous published works on various topics relating to pulmonary and critical care medicine. Since , Dr. Previously Dr. Glassman completed his residency in internal medicine at the Hospital of the University of Pennsylvania, and his fellowship in hematology and oncology at Cornell.
Former VP, Oncology Department, AbbVie; CMO, Ayala Pharmaceuticals An accomplished pharmaceutical executive and strategic business leader with extensive experience in the development of drugs from first in-human studies to approval and commercialization.
He brings innovative approaches to the process, leveraging advantageous regulatory pathways and close collaborations with investigators, patient advocacy groups and key academic and government consortiums. D and Ph. Horak brings more than 20 years of experience in the global pharmaceutical industry, predominantly focused on oncology drug development, and is a board-certified medical oncologist.
Nasdaq: ENZN. Horak has also held a number of senior research leadership positions in various pharmaceutical companies as well as at the National Cancer Institute NCI. During his career, Dr. Horak advanced multiple oncology treatments into the clinic and successfully led a number of FDA new drug applications. In addition to publishing over 90 scientific articles and book chapters, Dr. He also served on the editorial board of the scientific journal, Cancer Research. He trained at the world-renowned Cleveland Clinic and has been in practice for more than 13 years.
Kaplan is an authority on various aspects of the host immune response to mycobacterial pathogens, including the causative agents of leprosy and tuberculosis TB. Her work has encompassed developing a deep, holistic understanding of the cellular immune response and how this can be harnessed for host adjunctive therapies. She spent her career as an academic research scientist leading her laboratory in investigations focusing on human disease, exploring novel experimental medicine approaches that harness the immune response for disease control.
He is a Biomedical Scholar and Professor of Oncology at Georgetown University where he leads the development of a new innovative, high impact immune-oncology program to continue his scientific contribution and translate many of his discoveries into high-impact clinical trials. Khleif serve on many national and international committees driving the immune-oncology field and he is a scientific advisor for more than 15 immnue-oncology companies. During his tenure at the National Cancer Institute where he served the Chief of the Cancer Vaccine Section, he established one of the first immune therapy and cancer vaccine programs in the field.
Khleif leads an international program to develop cancer care programs in low income countries. Amongst others, Dr. Maisano is an experienced technologist passionate about creating software solutions that improve healthcare. She is an inventor of their oral delivery technology, led the development of their lead product through all stages of development, including NDA submission.
Roni is now a board member at Chiasma. Oppenheimer is board certified in Internal Medicine and Allergy and Immunology. Oppenheimer has participated well over clinical studies with over publications and has received numerous awards regarding his contributions in the field of allergy. He serves as both the associate and section editor of the Annals of Allergy Asthma and Immunology, co-section editor of Current Reports of Allergy and Immunology and serves as a reviewer for the Journal of Allergy and Clinical Immunology.
Pascheles joined Merck from Aventis Inc. He received his Ph. Former President, Global Clinical Development, Celgene is A C-Suite Executive with extensive early and late stage clinical drug development experience leading to the approval of over 10 novel therapies across a broad range of therapeutic areas.
She serves on the board of Homology Therapeutics. Reicin had a year career at Merck in which she had leadership roles across a wide variety of therapeutic areas. In her capacity as Vice President, Oncology, she led the Keytruda program and oversaw the initial development and filing activities worldwide, and the initiation of development plans in 7 different indications. Prior to Merck, Dr. Reicin was a faculty member at Columbia Medical School, and a physician and researcher at Columbia Presbyterian Hospital.
Ron is a physician executive with more than 25 years of healthcare experience in senior leadership roles in hospitals and health plans, venture capital, benefits management and strategic consulting. Werber had a 14 year tenure as a highly ranked biotechnology analyst at marquee Wall Street firms. As a registered patent attorney, Dr. Scott obtained his law degree from Northwestern University with a focus on business law. Scott obtained his Ph. Chief Medical Officer, Nevakar, Inc.
Somberg is a pharmaceutical executive with senior leadership experience in global pharma and contract research organizations. He is the former Chief Medical officer of Covance, Inc. He has authored more than scientific papers and presentations and is an Adjunct Assistant Professor in the School of Medicine, University of Pennsylvania.
Stein is also an active member of several professional and scientific societies and academic committees. BioSight Ltd, a pharmaceutical company developing innovative therapeutics for hematological malignancies and disorders, announced today that it has entered into a clinical trial agreement with the European Cooperative Group. The Study is expected to begin in Q4 Biond Biologics appoints Jerome Zeldis, M. Parking payable available at the building.
Entrance from HaMada St. Additional parking payable via app available at a parking lot on Pekeris St. We would be happy to hear from you and learn more about your company and technology. Please feel free to contact us at Info IsraelBiotechFund. Without that you can't afford to continue investing. Sometimes I invest with friends, but I prefer to find an exciting idea and evaluate it myself. If it's good, I will talk to my contacts, and then, if they are interested, they will join me.
What is highly important to me is that scientists who understand commercialization are on the board. These types of people are invaluable to the project. Scientists must dare. They cannot simply deal with knowledge, they should think about how to transfer knowledge, how to give something back.
It's important to do what you can, to think about whom you know and how you can help. Ultimately, helping to develop new things is good for you, good for your institute or company, for your country and for the world. We should develop things that are helpful. And if we make money doing it, there's nothing wrong with making money out of science.
Shmuel Cabilly holds a Ph. As head of a joint project between City of Hope Research Institute and Genetech, he developed a new technology for recombinant antibody production. Today, more than 20 drugs are based on this invention, which was patented as the Old Cabilly in and the New Cabilly in Cabilly also co-founded Ethrog Biotechnology, which was acquired in by Invitrogen, a worldwide supplier of products and services for life science research. Cabilly now serves on the board of several companies, including two Israeli incubators.
At what point did you become interested in investing in startup companies? After a particularly successful period in my career, I was compensated for some inventions. I earned a lot of money, at least more than I was accustomed to, so I decided to invest a percentage of it in early-stage companies. The idea was, and still is, not so much to earn money, but to have a way to be involved in startups.
My original objective was to establish a pool of money for investments and have the returns from those investments replenish the pool so it would sustain itself. That was about eight years ago, and since then, I've invested in about 35 startups. I had a steep learning curve, and it took lots of time. From an investment point of view, it's not something I would advise anyone to enter.
Miracles happen all the time, of course, but generally speaking, investing in seed-stage projects is more a philanthropic gesture than an investment. The chance of getting a return on your investment is very low. Maybe others do better, but personally, the moment I invest, I write in my notes that the value of this money is now zero.
I feel better thinking like this; it helps me avoid frustration. How do you determine which projects are worthwhile? In the beginning, I selected opportunities because I believed in the scientific contribution of the project. The idea made sense and, on that basis, I gave it, say, a 90 percent chance of success. But in time, I learned there are many other influencing factors.
Every startup begins with an inventor, an investor and someone who manages the company. Each of them comes at the project from different perspectives. It's a brittle combination. Great ideas fail for lack of good management, for internal conflicts, for lack of follow-on investment. I'm not capable of foreseeing which of the companies that I invest in will succeed. I still invest based on the merit of the invention, but I no longer believe that's the primary factor in the success of a project. Is there a comfortable range?
I don't care to give a specific figure, but I've invested in over 35 startups. Luckily most of them die at the beginning. The longer they survive, the more money you pump into them. Israel is a good place to invest in startups because launching them here is cheaper than in the US, for example.
But raising second and third rounds is very tough. This is part of what I have learned. When you explore the feasibility of investing in a project, you must attempt to determine whether the company can be on its feet in a relatively short period of time. The idea may be great, but if you see the project doesn't have a good chance to raise a second or third round, then you have to determine whether to invest at all.
Sometimes it's better not to invest, to kill an idea. This is a hard choice, but if the project fails, the young people involved in the project could invest eight years of their lives and have nothing to show for it. That will put them in a very difficult position later on. Still, you never know. Given your low expectation for any significant return on investment, why continue to invest in startups?
Three or four years ago I was more willing to put money into projects than I am today. Partly because the plan I had to create a self-sustaining investment pool has not worked. As I said, I've invested in 35 companies, but even though four of them are now publically traded, I have not recouped the real worth of my initial investment. So I'm trying to restrain myself more these days. But every time someone comes with a great idea, I get excited. And I'm confronted with great ideas all the time!
So it's quite tempting. For me, it's not a money lottery; it's a results lottery. I know you consider each project individually, but in general do you prefer an industrial partner or a venture capital firm?
In Israel, startup companies don't much like VC firms. If the company is developing only one product, then maybe going with a venture capital firm is OK. But if the company intends to develop several products, it's usually better to join up with a larger company that can help develop the follow-on products.
How long is your money typically tied up? If the project involves developing a drug for instance, then, for me, the satisfaction comes from having the drug reach the market. I define success as having the company succeed, meaning it stands on its own and makes more products.
Exit strategies or end goals are different for different members of the project. The CEO, for instance, may see a chance to make money relatively early on and decide it's better to take it than wait and risk losing everything. I understand because these are typically younger people who want to buy a new house or something like that for the family. I prefer to continue on until there is a finished product - a drug, a device, whatever.
Given that you take a long-term approach to investing, what kind of ROI do you expect? Honestly, all I hope for is to make enough from some companies to be able to invest in other companies. What's your attitude about co-investors? My first interest is in the company itself. A company should raise as much money as possible, because the more it has the better its chance of success. Of course, if there are too many investors, it's a burden on the company. So if a company can get all the money needed from one or two investors, that's generally better.
But I personally don't require that other investors be committed before I invest. If making money is not your primary motivation for investing in startups, what makes it worthwhile? Being part of a success is my reward. For some people, adding one more zero to their bank account balance is their motivation. Beyond a certain point, however, you have enough money. Your life is not going to change substantially if you have more.
So you look for ways to enjoy it. I enjoy being part of a successful venture. I would rather be the inventor than an investor, but I can't always be the inventor. Investing allows me to remain involved with inventions. Kotler earned a masters degree in molecular biology before studying law at the Hebrew University in Jerusalem.
He subsequently worked as a prosecutor in the Jerusalem District Attorney's Office before founding KoVax, a firm that specializes in the development and manufacture of aquaculture vaccines. Though you're not an angel investor, per se, your family has invested in several promising projects. How have you found the technologies that interest you? The first touch is always with the scientists.
I have a background in biology, so I read papers before I approach a scientist. They are always willing to talk about what they are doing. But I always begin with a personal approach and talk directly with the scientist who discovered the invention. How did you become an entrepreneur? He is a professor at the Hebrew University in Jerusalem, and he had some minor legal issues concerning the technology. Not with the Hebrew University, but with things relating to grants.
I helped resolve the issues, which were very simple. But after I read all the papers, I decided I wanted the project myself. So that's how I got involved in KoVax. Koi are extremely valuable fish. That's the market in the US and Europe. But the vaccine also works for the common carp, which is the most edible fish in the world.
Approximately 8 billion carp are consumed annually in China, Indonesia and Malaysia. The disease has decimated the carp population, so the price of the fish has nearly tripled. That's a huge price jump for people in this part of the world.
Vaccinating the fingerlings in the hatcheries will eventually bring down the price of the fish significantly. Where is that company in its development today? After we took it out of the Hebrew University, I picked up a small factory and began addressing the regulatory hurdles.
We were a very small company at the time. We had only four people. My wife joined me in this venture, leaving her position as a department manager at Intel, the big computer chip maker. We decided to take on the project as a family business. After two and a half years, we cleared the Israeli regulatory process. After that the vaccine will be licensed and offered over the counter in the US.
We will produce it, but we've signed with a big pharmaceutical company to distribute it. We're currently selling to Asia, and the next step will be Europe. Are you working on other projects in parallel with KoVax? We actually have four companies at present. Two years ago we began working on a project involving Hepatitis C. The treatment for Hepatitis C is a weekly injection of interferon for a full year. Half of the people who receive the injections are completely cured, but the other half are either non-responsive or they relapse.
So for roughly 50 percent of the patients, the costly treatment is ineffective and therefore a waste of money. Also, patients suffer severe side effects. They feel like they have a severe flu for half of every week, and just when they start feeling better, it's time for another injection.
Why put people through this if they are not responsive to the treatment? Our diagnostic test predicts, with 96 percent accuracy, which patients will respond well to interferon treatment. What's the size of the market? In the US alone, roughly 35, cases of Hepatitis C are diagnosed each year.
Interferon treatment is covered by insurance, so if we can go to the insurance companies and say we can save you about half of what you spend for interferon annually, we will have their attention. How does the diagnostic test work? Every patient with Hepatitis C gives a liver sample to the hospital where they are diagnosed and being treated. We got liver samples that have been embedded in paraffin from local hospitals.
Most of the samples were taken seven plus years ago. We were able to predict with 96 percent accuracy those patients who responded to interferon and which ones didn't. The test is pretty standard. If the expression is high in certain genes that we've identified, then the patient will be unresponsive to interferon. If it's low, the patient will be responsive. The degree of responsiveness is calculated using an algorithm developed at the Hebrew University.
Where are you in your proof of concept? Ours is an in vitro device. Initially we tested 28 people—14 were clearly responsive to interferon, 13 tested as unresponsive. Only one out of the 28 test results was a mistake. So those results were a good indicator that we were on the right track. Many people have tried to do this, so there was a lot of data on genes that had been tested. We used our algorithm to test the data, and, again, we got great results—96 to 98 percent accurate prediction.
Next, we tried working with blood samples, because taking a blood sample is much simpler. We did a double-blind blood test on 50 people. Unfortunately, we were only at 70 to 75 percent with blood samples, and that's not good enough. We're still working on improving that. Currently, we are conducting another round of liver samples, and we hope to finish this process in a couple of weeks. Liver samples are already part of the protocol in the US. When someone is diagnosed with Hepatitis C, their doctor automatically orders a liver sample, so samples are readily available.
Once we conclude this latest round of testing, we will have enough information to decide which route to take in the US, our first market because of its size. What do you have to do to have the test approved for use in the US? There are two main regulatory routes in the US.
One is the Food and Drug Administration. The other way is to team up with one of the big lab companies, a company like LabCorp, and go the CRS clinical research site route. This is the more appealing route for us, to try to get a good deal with a big company. What are the other projects you're currently working on and how mature are they? It's a completely new mechanism. We believe this same mechanism will also work for people who have lymphoma. But these types of projects are very long term, 12 to 15 years.
We've had good results in the research stage, now we will begin development. We hope to begin Phase1 in the next year. The other project I'm currently working on has nothing to do with biology. We're treating water, transitioning gray water to irrigation-grade water and desalinating seawater. Usually salt is removed from seawater by running the water through some kind of membrane.
As the seawater passes through the membrane, the salt is removed. Our technology uses magnetic energy to treat the water. In Israel and in a growing number of places around the world, people buy water by the cubic meter. Our technology enables us to sell the water for about half of what the government charges for water.
We've already entered agreements with a couple of big laundries, which use huge amounts of water, something like cubic meters of water daily. Our method of treatment enables us to recycle the water and use it again and again for virtually every purpose except drinking. Right now the customer does not buy the machine, they just pay for the water. The market for this kind of product is exponential given the growing shortage of clean water. National Center for Biotechnology Information , U.
Journal List Cell Cycle v. Cell Cycle. Published online May Catarina Wylie. Author information Copyright and License information Disclaimer. Corresponding author. Correspondence to: Catarina Wylie; Email: moc. Jack Lahav Jack Lahav specializes in the launch and growth of new businesses. Open in a separate window. Max Herzberg Dr.
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